Until the end of the XVIII century, mineralogy as an independent science did not exist. Mineralogy, in essence, was called the science of ore deposits in its modern sense. Then, there was no clear definition of the term "mineral." This concept included not only minerals in the proper sense of the word, but also ores, rocks, and fossils. Due to the low general level of knowledge by the middle of the XVIII century, there was no information on the chemical composition of minerals. Of all the chemical elements in the time of Lomonosov (until 1765), only 17 were known: carbon, phosphorus, sulfur, iron, nickel, cobalt, copper, zinc, arsenic, silver, tin, antimony, platinum, gold, mercury, lead and bismuth. Later, until 1790, 11 more chemical elements were discovered: nitrogen, oxygen, chlorine, manganese, barium, molybdenum, tungsten, tellurium, hydrogen, zirconium, uranium. Lomonosov laid the chemical study of minerals using qualitative and primitive quantitative analyzes. Along with chemical analyzes, physical experiments were carried out to study minerals. The scientist had the idea of synthesizing minerals, artificially obtaining salts, a number of ore and other minerals. Thanks to the efforts of Lomonosov, the first scientific chemical laboratory was built and opened in St. Petersburg. Scientists covered various issues of mineral formation, including deposition methods and sources of mineral matter, and paragenetic associations of minerals.