Cimanuk River is the second largest river in West Java after the Citarum River. It is many used as a source of raw water in the Regional Drinking Water Company (PDAM). However, water quality of the Cimanuk River considered polluted. This research aims to assess water quality of the Cimanuk River based on the water quality standards of World Health Organization (WHO), United States Environmental Protection Agency (US EPA), Environmental Quality Standard (EQS), and Regulation of the Governor of West Java (WJP) Class 1. Water sampling stations of Cimanuk River at Sukatani, Boyongbong, Sukamantri, Tomo, Monjot, and Kertasmaya. The STORET method used to assess the water in the Cimanuk River from years 2013 to 2017. Base on ten parameters, this study found that the Cimanuk River is not meet the water quality standards with the value of TSS (120,93±99,06 mg/L), DO (6,71±0,96 mg/L), BOD (7,43±3,28 mg/L), COD (19,70±11,77), NH3 (0,43±0,33 mg/L), NO3 (4,75±4,19 mg/L), PO4 (0,66±0,28 mg/L), and Total Coliform (66600±57415 MPN/100mL). The degradation of the water quality in the Cimanuk River indicated by the decreasing STORET score. STORET score of the Cimanuk River ranging from -36 to -120. The water quality status of the Cimanuk River has heavily polluted. Water pollution in the Cimanuk River is a threat to the sustainability of water resources. Nowadays, the Cimanuk River is not suitable for the drinking water source. However, it is feasible to irrigate agricultural land. Therefore, an increase in collaboration between local communities, regional government, and private sectors is needed to conserve the Cimanuk River.