Pharmacokinetic aspect of Carica papaya leaf extract after oral administration

The pharmacokinetic data were needed to determine the dose and frequent of drug. Carica papaya leaves have potency to develop a new herbal medicine. The research aimed to explore the excretion rate of oral administration of Carica papaya leaf extract. The time series experimental was conducted to six male and health rats. Single dose (900 mg) of Carica papaya leaf extract was given orally. Urines were collected in range 0 to 6 hr, 6 to 12 hr, 12 to 24 hr and 24 to 48 hr after oral administration. Flavonoids urine were measured by HPLC. Flavonoids detected in range 0 to 6 hr were 0.0721mg/mL. The level of flavonoid increased in 6 to 12 hr (0.0722 mg/mL), 12 to 24 hr (0.1306 mg/mL) and 24 to 48 hr (0.1800 mg/mL). The excretion rate in range 0 to 6 hr was 0.02662 mg/hr, 6 to 12 hr was 0.02888 mg/hr, 12 to 24 hr was 0.03428 mg/hr and 24 to 48 hr was 0.03574 mg/hr. Total flavonoid have been excreted in 48 hour was 4.73 %. Carica papaya leaf extract was excreted in 6 hr after oral administration and need more than 48 hr to clear all flavonoid from plasma.