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The Effect of Atorvastatin Administration before Percutaneous Coronary Intervention on Stable Coronary Artery Disease Against Event of Periprocedural Myocardial Infarction

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Published under licence by IOP Publishing Ltd
, , Citation L P C Dewi et al 2020 IOP Conf. Ser.: Earth Environ. Sci. 441 012191 DOI 10.1088/1755-1315/441/1/012191

1755-1315/441/1/012191

Abstract

Statin administration before Percutaneous Coronary Intervention procedures (PCI) is proved in reducing the incidence of Myocardial Peri-Procedural (PMI) infarction. This research was to compare between of pre-treatment 40mg Atorvastatin administered two hours before PCI in Stable Coronary Artery Disease (SCAD) patient and without pre-treatment in reducing the rate of periprocedural myocardial infarction. This study was a Clinical Trial with pretest-posttest control group open-label randomized design. Data were analyzed using Kolmogorov Smirnov Sample test and Chi Square Test. The PMI incidence in the atorvastatin group was 0% and in the control group was 8.3% (p = 0.489). The maximum CK-MB value after PCI in the atorvastatin group was 6.4ng/ml and 25.49ng/ml in the control group. Administration of 40mg Atorvastatin in SCAD patients before undergoing PCI shows a tendency of a decrease in PMI incidence.

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10.1088/1755-1315/441/1/012191