Abstract
Problems related to controlled drug release are important to immediately find a solution because of the dangers of drug side effects if consumed repeatedly every day. The drug used is Nifedipine which is a hydrophobic drug. This research used a synthetic combination of poly(caprolactone) and poly(ethylene glycol) with surfactants in the form of tween 80 and span 80 while the method used was microencapsulation. Microencapsulation is a process in which active substances are coated by extremely small capsules. Once the drug was in the intestine, it was released in a controlled manner so as to minimize side effects and maximize drug release. The results showed that the composition of the best poly(caprolactone) (PCL): (PEG) poly(ethylene glycol) combination was 80:20 with a molecular weight of PEG 400 g/mol. The result of the encapsulation efficiency percentage obtained 97.84% ± 0.01 and the result of dissolution test was 44.77%.
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