Response of blood glucose level in hyperglycemic Rattus norvegicus towards giving of mixture of VCO and Olive oil with Vitamine E and their effects on the liver

Virgin coconut oil (VCO) and olive oil are edible oil containing antioxidant that can prevent free radicals in Rattus norvegicus hyperglycemic due to the damage of pancreatic beta cell after alloxan injection. Virgin coconut oil and olive oil are fatty acids that when being consumed will affect the diameter of hepatocyte cells. this study aims to analyze the response of blood glucose levels in hyperglycemic Rattus norvegicus after administration of a mixture of VCO and olive oil with vitamin E and its effects on the liver. Research materials were twenty male Rattus norvegicus were. Randomized Factorial Design was used in four treatment groups including P1 was control, P2 was mice injected with alloxan, P3 was mice injected with alloxan plus 0.1 ml/BW of each VCO and vitamin E and P4 was mice injected with alloxan plus 0.1 ml/BW of each olive oil and vitamin E. Each treatment was replicated 5 times. Feed and water were provided ad libitum for four weeks. The result showed that there was no significant difference in the level of blood glucose between P3 and P4 but significant difference with P1 and P2. The diameter of hepatocyte cells and Hepatosomatic Index not significant than the other treatments. It can be concluded that VCO and olive oil are equally capable of decreasing blood glucose and does not cause negative effects on the liver.