Antidiabetic and cytotoxic activities of ethyl acetate extract of Piper betle Leaves

Antidiabetic and cytotoxic activity examination of ethyl acetate extract of betel leaf (Piper betle L.) has been done. The antidiabetic activity test was performed in vitro by investigating the inhibition of the extract against the activity of a-glucosidase enzyme. The IC₅₀, of the ethyl acetate extract of betel leaves against the a-glucosidase were 48.42 ppm. The cytotoxic activity of ethyl acetate extract was carried out by using Brine Shrimp Lethality Test (BSLT) method. Data analysis was done with Probit Analysis, it was found that ethyl acetate extract of betel leaf had high cytotoxic activity with LC₅₀ value of 3.92 ppm and its standard error of 0.42 ppm.