Optimization of time-dose fractionation radiotherapy scheme by simulated annealing with consideration of biological factor

Ionizing radiation for cancer treatment also known as radiotherapy has undergone development for more than century. Radiation kills cancer by giving partially or entirely all of the energy to the tumor tissue, especially in the DNA. If tumor or a cancer is irradiated by radiotherapy, there is no way to avoid the tissues near cancer will be affected by the radiation. As a result, the healthy tissues near tumor will lose their functionality, or worse, there may appear a new tumor in that tissues. Therefore, it should be done some improvement in the quality of radiotherapy, one of the examples is optimization of time-dose fractionation radiotherapy scheme. To optimize the fractionation dose, is made a program in MATLAB using simulated annealing as the optimization method. The objective function is Biologically Effective Dose of cancer, with constraints are Biologically Effective Dose of the healthy tissues around cancer. After obtaining the optimum dose per fraction, the data will be analyzed for the total and fractionation time. Thus, it would be obtained the optimum of time scheme and dose fractionation of cancer. The result of this research will show the dose per fraction from the total time in 10 until 60 days in both of the treatment schemes, the value of Biologically Effective Dose of the cancer, and the optimum of dose per fraction from both of the treatments.