Abstract
The relationship between diabetes and hyperlipidaemia is a well-recognized phenomenon. Djengkol (Archidendron pauciflorum) fruit peels have been used traditionally as medicinal plant for treats diabetes. The present study investigated the antihyperlipidemic activity of ethanol extract from A. pauciflorum fruit peel on the diabetic female Wistar rats. The diabetic condition was induced by intravenous injection of streptozotocin at a dose of 65 mg/kg BW. The ethanol extract of Djengkol at a dose of 385, 770, and 1540 mg/kg BW as well as glibenclamidee at a dose of 10 mg/kg BW as reference administered daily for 14 days to the diabetic rats. The result did not show dose-response manner, which the extract treatment at a dose of 770 mg/kg BW slightly decreased the cholesterol total, triacylglycerol, LDL cholesterol and atherogenic indices, as well as significantly increased HDL cholesterol compared with the reference group (p<0.05). Overall, our data suggest that A. pauciflorum fruit peel extract has an antihyperlipidemic potency in streptozotocin-induced diabetic female Wistar rats" rather than "In conclusion, the A. pauciflorum fruit peel extract has an antihyperlipidemic potency in streptozotocin-induced diabetic female Wistar rats.
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