A Stochastic Differential Equations Model for Internal COVID-19 Dynamics

In this article, we analyze stochastic differential equations model for internal coronavirus (COVID-19) dynamics. The stochastic differential equations model are expressed using the Ito’s formula. The Environmental stochasticity in this dynamical model is presented via parameters disturbance which is the standard method in the stochastic differential equations(SDEs) in the population modeling. We than prove that this model decided in this paper have a unique global positive solution because this is fundamental in any population dynamics model. The main aim of this paper, we formulate the interaction of coronavirus COVID-19 with host cells and presented the conditions required in order to the COVID-19 to die out. And this results also illustrated by computer simulation.

where the first integral on the right of equation (2.4) is Riemann integral, and the second is stochastic integral.

A stochastic Differential Equations (SDEs) Model derivation
In this paper, we suggest a vaccine that works to reduce the interaction between infectious virus particles and healthy cells . As well as a vaccine that does not form virus particles in a proper way, and this leads to new viruses that are weak, not capable on reproduction. The rate at which viruses are cleared may be affected by various of factors including binding and entry into the host cells. Because mortality rates from virus particles and cells affected via several complex biological phenomena for this reason we thing there is stochastic in this death average. This will give us important incentive to think that's what we can insertion environmental stochastic in the a kill rate of infected cells which contain receptors angiotensin converting enzyme 2 (ACE-2) .So the stochastic differential equations system will be as follows. . 3) At this system 1 ( ) and 2 ( ) are independent stander wiener process or Brownian motion . If there is stochastic in parameters for example coronavirus (COVID-19) death average , it is a normal method to present environmental stochastic into the parameters in this system. You can note the intensity of the noise and the Wiener process ( ) are the similar for infected and uninfected ACE-2 cells, but dissimilar for the ACE-2 host cells and COVID-19. Since although biological agents that influence all deaths average of uninfected and infected ACE-2 host cells may be probable to be very alike different biological agents affecting Coronavirus particles and ACE-2 cells. So, though there is no detailed biological data, the noise intensity is likely and the wiener process ( ) are different for infected and uninfected ACE-2 cells As a first simplified approximation, it is reasonable to assume that these are the same. since coronavirus particles and angiotensin converting enzyme2 cells are abundant more dissimilar biological units it appears much extra probable that and ( ) are dissimilar among the infectious coronavirus atoms and ACE-2 cells. You should note the state with no casualty virus particles and no infected cells can described ,as follows ( 1 , 2 , 3 ) = ( ⁄ , 0,0) it is fixed point in the deterministic model but not for random differential equations ( SDEs) model .In the SDEs model the last two equations ( 2 , 3 ) = (0,0) are still a stochastic stability ,but state is different for the first equation (3.1) of the procedure which we will see advanced differs rundamally about the value ⁄ .  Represents the death rate per capita from infectious virus particles 1 and 2 Represent a parameter used to model the stochastic or randomness in the evolution, which will cause local deviation from the typical (exponential) 1 ( ) and 2 ( ) Represent an increment Weiner process which models the randomness in the evolution

4.Existence of Unique Nonnegative Solution
To show this model make sense and can be applied to explain the life cycle of the virus, we must show that this, A stochastic differential equations model does not only have a single global solution, but has a unique non-passive universal solution. In this article we suppose (Ω, ℱ, {ℱ } ≥0 , ℙ) to be possibility space complete with a filtration{ℱ } ≥0 satisfying the normal condition(i.e.it is growing and right uninterrupted whereas ℱ 0 covers all ℙ -null sets), and suppose W(t) be a constant Wiener procedure defined on the possibility space. Through this paper ˄ b denote min(a ,b) and ˅ b denote max (a,b) ,also suppose ++ 3 = { ∈ 3 : > 0, for all 1 ≤ ≤ 3}and let ( ) = ( 1 ( ), 2 ( ) and 3

( ))
Let us give this lemma, before proving the main theorem  on other words this means that, to finish the proof we will show that ∞ = ∞ . If this declaration is not true, so there is a couple of constant > 0 and ∈ (0,1) so that { ∞ ≤ } > .

Asymptotic behavior
In the study the dynamical behavior of for Internal COVID-19 Dynamics, it is important for us to study and consider the conditions required in order to the coronavirus COVID-19 to die out, i.e. when 2 ( ) → 0 and 3 ( ) → 0, as → ∞.  By using Ito's formula we find After simplifying we find We can rewrite the term In the following method let us consider the matrix Because of the last matrix is negativedeterminant with main (negative) eigenvalue so: .
When we substituting this in inequality (5.1) we find If we integrate the above inequality and by using the large number theorem [ 8], we have Note that the conditions of theorem 5.1,will always be achieved .If 1 2 and 2 2 are big sufficient these situations will constantly be verified .This exciting result as it declares that if stochastic alterations are big so coronavirus COVID-19 and infected cells will at all times die out, whatsoever the extra parameter values, even though 0 > 0 .We now will concentrate on 1 ( ) . We'll show at the end that 1 ( ) is expantialy stable in supply in the sense that it stabilizes about the value ⁄ . In order to get this we will present the new stochastic procedure ( ) which is can defined via its primary Condition (0) = 1 (0) and SDE ( ) = ( − ( )) − 1 ( ) 1 ( ).
We will expression that in the limit as becomes great 1 ( ) can be approximated by ( ) so to proof this we will present another stochastic function ( ) which is presented by the initial condition ( ) = 1 (0) and SDE.

Computer Simulations
In this section, we will try to support our analytical resulting numerical simulation produced in theorems(5.1) and(5.2). We find by the theoretically results the coronavirus particles and the infected cells are stable and goes to zero if the two conditions submitted in theorem 5.1 are satisfied . Also we note that we can estimated 1 ( ) via ( ) where ( ) is the mean returning process. The computer simulation programs have been written in MATLAB by using Euler Maruyama method (EM) our results were confirmed by running them frequently and extensively examination the result. t. So the infected cells ( 2 ( ) )tend to zero exponentially as → ∞.