Serum Immunoglobulins (IgG and IgA) Level in Chronic Sinusitis and Otitis Media Patients

Sinusitis and otitis media are two of the most common indications for antimicrobial agents of upper respiratory tract infection. This study was aimed to determine the effect two chronic upper respiratory tract diseases (sinusitis and otitis media) on immunoglobulins levels via assessment the level of serum IgG and IgA in sinusitis and otitis media patients using single radial immune diffusion technique. A total of 100 sera samples were included in this study, all of them were adults, 40 samples collected from each of sinusitis and otitis media patients. Control group was included 20 samples from healthy donors. The mean of IgG concentrations in sinusitis patients (1078.6mg/dl) revealed significant decreasing comparing with control group (1249.82mg/dl), whereas IgG level in otitis media patients (1338.77mg/dl) recorded non significant alteration. IgA mean of otitis media (388.26 mg/dl) significantly decreased compared to control group (235.3 mg/dl) while IgA mean of sinusitis samples (244.4 mg/dl) did not record any alteration. This study concluded that chronic sinusitis cause decreased of IgG while chronic otitis media cause increased IgA level. In general the immunoglobulins concentrations were mild moderate.