Abstract
Background: Due to their unique properties, zinc oxide nanoparticles (ZnO NPs) gained a broad utilization in nano-based industries and medicine, which may expose human to increased levels of NPs. Zinc oxide (ZnO) is one of the most commonly utilized material in diverse industrial fields such as dyes, additives, rubber, ceramics, chemical fibers, electronics, medical diagnosis, sunscreens, cosmetics, personal care products, and food additives. Nanomaterial describes tiny materials, decreasing the size of the nanoparticles leads to the increase in surface area and provides the absorption possibility for further chemical molecules on the surface and this increases the reactivity of the particles, leads to increase in the effects of toxicity in these materials, ZnO nanoparticles effectively absorb UV-A radiation, as they are used as biomarkers for Cancer Treatment and for Biomedical Applications, these nanoparticles display antifungal, and antibacterial effects.Exposure to zinc oxide nanoparticles has been increasing steadily, causing more attention being paid to their potential toxicity, including cytotoxicity and genotoxicity. Hence this study aimed to investigate the effect of ZnO NPs on thyroid hormone Triiodothyronine (T3), Thyroxine (T4) and (Thyroid stimulating hormone) TSH as well as testosterone hormone in male adult rats. While Methods: A total of 54Spargue-Dawley albino adult male rats were divided into nine groups each of 6 rats, daily treated intra-peritoneal with ZnO NPs two different doses (30, 60)mg/kg in three different periods of time (7,14 and 28) days, as following: Control groups (group 1,2,3): respectively received intra-peritoneal injection with distilled water for(7,14, and 28) days, Experimental groups (group 4,5,6): they were rats respectively received intra-peritoneal dose ( 60mg/kg ) of zinc oxide nanoparticles for (7,14, and 28) day, and (group 7,8,9) experimental groups: were rats respectively received intra-peritoneal dose (30 mg/kg) of zinc oxide nanoparticles for (7,14, and 28) days. theResult: Data showed high significant decrease(p<0.01) in level of T3 and T4 and level of testosterone also decrease at high and low dose for 7,14 and 28 days, while the level of TSH showed no significant change in all dose and duration of time. Results of the current study suggested the possible time and dose effects disrupting of AgNPs on thyroid gland function and testes in male rats
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