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The following article is Open access

Velocity oscillations in actin-based motility

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Published 12 March 2008 Published under licence by IOP Publishing Ltd
, , Citation Azam Gholami et al 2008 New J. Phys. 10 033022 DOI 10.1088/1367-2630/10/3/033022

1367-2630/10/3/033022

Abstract

We present a simple and generic theoretical description of actin-based motility, where polymerization of filaments maintains propulsion. The dynamics is driven by polymerization kinetics at the filaments' free ends, crosslinking of the actin network, attachment and detachment of filaments to the obstacle interface and entropic forces. We show that spontaneous oscillations in the velocity emerge due to a push–pull mechanism in a broad range of parameter values, and compare our findings with experiments.

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10.1088/1367-2630/10/3/033022