A number of portable gamma cameras for medical imaging use scintillator-CCD based detectors. This paper compares the performance of a scintillator-CCD based portable gamma camera with either a columnar CsI:Tl or a pixelated GOS scintillator installed. The CsI:Tl scintillator has a sensitivity of 40% at 140.5 keV compared to 54% with the GOS scintillator. The intrinsic spatial resolution of the pixelated GOS detector was 1.09 mm, over 4 times poorer than for CsI:Tl. Count rate capability was also found to be significantly lower when the GOS scintillator was used. The uniformity was comparable for both scintillators.