Oligostilbenoids from Vatica pauciflora and the Oxidative Effect on Chang Cells

Phytochemical studies on the woods and twigs of Vatica pauciflora (Dipterocarpaceae) have been conducted. The woods and twigs of V. pauciflora were extracted in methanol and ethanol respectively with Soxhlet apparatus. The crude methanol extracts from the woods were semi-purified by vacuum liquid chromatography to give 14 fractions (VMB01-VMB14). The VMB10 was further purified by radial chromatography to give pure dimmer stilbenoid. The same technique has been employed on the crude ethanol extracts from the twigs in which one pure fraction, VER612 was obtained. Based on the UV, IR, NMR and mass spectral data, the pure compounds were characterized as -viniferin and vaticanol G respectively. An oxidative damage test which was done on Chang liver cells has shown that -viniferin has a potential to be a chemopreventive agent to protect liver cells from oxidative damage.