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The following article is Open access

Degradation of platinum based anticancer drugs by methionine: An EXAFS study

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Published under licence by IOP Publishing Ltd
, , Citation K Provost et al 2009 J. Phys.: Conf. Ser. 190 012206 DOI 10.1088/1742-6596/190/1/012206

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1 ICMPE, UMR 7182 CNRS-Université Paris 12, 94320 Thiais, France

2 Laboratoire de Pharmacie Galénique, Université Paris Descartes, 75006 Paris, France

3 EXAFS Beamline, ELETTRA, Sincrotone Trieste, 34012 Basovizza, Trieste, Italy

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1742-6596/190/1/012206

Abstract

We characterized the structures in solution of carboplatin and oxaliplatin degradation products in presence of a large excess of methionine (Met). The reaction of carboplatin leads to the formation of cis-Pt(Met)2 while, in the case of oxaliplatin, methionine displaces only the oxalate ligand to form Pt(diaminocyclohexane)(Met).

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10.1088/1742-6596/190/1/012206