R A Bazemore et al 2012 J. Breath Res. 6 016002 doi:10.1088/1752-7155/6/1/016002
R A Bazemore1, Jason Feng2, Leland Cseke2 and G K Podila1,3
Show affiliationsVolatile chemical profiles collected from the headspace of Aspergillus fumigatus (a pathogenic fungus that causes invasive pulmonary aspergillosis, allergic bronchopulmonary aspergillosis and chronic fungal sinusitis) grown on media with the connective tissue protein elastin, found in lung tissue, contained a large abundance of the sesquiterpene farnesene (3,7,11-trimethyl-1,3,6,10-dodecatetraene) and, depending on extraction time and sorbent material, other farnesene isomers and sesquiterpenes such as bisabolene (methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohex-1-ene). When human lung cells were cultured externally and infected with A. fumigatus, farnesene was also detected in each model lung system. Volatiles measured from cultured nasal lavage collected from a patient diagnosed with chronic fungal sinusitis, a condition frequently caused by A. fumigatus, revealed the presence of another pathogenic fungus, less frequently responsible for sinusitis, Epicoccum nigrum. The volatile profile of E. nigrum differed markedly from that of A. fumigatus with no sesquiterpenes detected.
Issue 1 (March 2012)
Received 26 April 2011, accepted for publication 15 November 2011
Published 10 January 2012
R A Bazemore et al 2012 J. Breath Res. 6 016002
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Brian P Dolan 2011 J. Phys. A: Math. Theor. 44 175001
Poulomi Sadhukhan and Somendra M Bhattacharjee 2010 J. Phys. A: Math. Theor. 43 245001
Yoshiki Matsuda et al 2008 J. Phys. A: Math. Theor. 41 324012
Andrea Velenich et al 2008 J. Phys. A: Math. Theor. 41 235002
E Brion et al 2007 J. Phys. A: Math. Theor. 40 1033
Matej Praprotnik et al 2007 J. Phys. A: Math. Theor. 40 F281
Kenji Kajiwara et al 2007 J. Phys. A: Math. Theor. 40 12661
Oliver Rübel et al 2009 Comput. Sci. Disc. 2 015005