Variation of green vegetation cover influences local climate dynamics, exchange of water–heat between land and atmosphere, and hydrological processes. However, the mechanism of interaction between vegetation and local climate change in subtropical areas under climate warming and anthropogenic disturbances is poorly understood. We analyzed spatial–temporal trends of vegetation with moderate-resolution imaging spectroradiometer (MODIS) vegetation index datasets over three sections, namely urban, urban–rural fringe and wildland along an urban–wildland transect in a southern mega-city area in China from 2000–2008. The results show increased photosynthetic activity occurred in the wildland and the stable urban landscape in correspondence to the rising temperature, and a considerable decrease of vegetation activity in the urban–rural fringe area, apparently due to urban expansion. On analyzing the controlling factors of climate change and human drivers of vegetation cover change, we found that temperature contributed to vegetation growth more than precipitation and that rising temperature accelerated plant physiological activity. Meanwhile, human-induced dramatic modification of land cover, e.g. conversion of natural forest and cropland to built-up areas in the urban–rural fringe, has caused significant changes of green vegetation fraction and overall primary production, which may further influence local climate.