Roger J Narayan et al 2008 Biomed. Mater. 3 034107 doi:10.1088/1748-6041/3/3/034107
Roger J Narayan1, Ravi Aggarwal1, Wei Wei1, Chunming Jin1, Nancy A Monteiro-Riviere1,2, Rene Crombez3 and Weidian Shen3
Show affiliationsImplantable blood glucose sensors have inadequate membrane–tissue interfaces for long term use. Biofouling and inflammation processes restrict biosensor membrane stability. An ideal biosensor membrane material must prevent protein adsorption and exhibit cell compatibility. In addition, a membrane must exhibit high porosity and low thickness in order to allow the biosensor to respond to analyte fluctuations. In this study, the structural, mechanical and biological properties of nanoporous alumina membranes coated with diamond-like carbon thin films were examined using scanning probe microscopy, nanoindentation and MTT viability assay. We anticipate that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function.
87.85.Qr Nanotechnologies-design
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
81.05.Rm Porous materials; granular materials
87.16.D- Membranes, bilayers, and vesicles
Issue 3 (September 2008)
Received 14 January 2008, accepted for publication 28 March 2008
Published 8 August 2008
Roger J Narayan et al 2008 Biomed. Mater. 3 034107
Giuseppe Zaccai 2003 J. Phys.: Condens. Matter 15 S1673
Sunil K Sinha 2001 J. Phys.: Condens. Matter 13 7511
Reese Salmon et al 2002 Eur. J. Phys. 23 249
Avner Peleg and Yeojin Chung 2003 J. Phys. A: Math. Gen. 36 10039
Gregory S Mitchell and Simon R Cherry 2009 Phys. Med. Biol. 54 1291
Sung-Joon Ye et al 2004 Phys. Med. Biol. 49 387
Tom Timusk and Bryan Statt 1999 Rep. Prog. Phys. 62 61
Yeojin Chung and Avner Peleg 2005 Nonlinearity 18 1555
Patrick J Sutton et al 2003 Class. Quantum Grav. 20 S815