Chen Chen et al 2007 Biomed. Mater. 2 L1 doi:10.1088/1748-6041/2/4/L01
Poly(lactic acid) (PLA) based nanocomposites—a novel way of drug-releasing
FREE ARTICLEChen Chen1, Gang Lv1, Chao Pan1, Min Song1, Chunhui Wu1, Dadong Guo1, Xuemei Wang1, Baoan Chen2 and Zhongze Gu1
Show affiliationsCOMMUNICATION
In this communication, poly(lactic acid) nanofibers have been fabricated by electrospinning and then poly(lactic acid) (PLA) based nanocomposites have been prepared by accumulating anticancer drug daunorubicin on PLA nanofibers combined with TiO2 nanoparticles. Our atomic force microscopy (AFM) and laser-scanning confocal microscope (LSCM) studies demonstrate that the respective drug molecules could be readily self-assembled on the surface of the blends of nano-TiO2 with PLA polymer nanocomposites, which could further efficiently facilitate the drug permeation and accumulation on the target leukemia K562 cells. Besides, the respective new nanocomposites have good biocompatibility, ease of surface chemistry modification and very high surface area, which may afford the possibility for their promising application in pharmacology and biomedical engineering areas.
- PACS
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87.85.Qr Nanotechnologies-design
- Subjects
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Soft matter, liquids and polymers
- Dates
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Issue 4 (December 2007)
Received 16 January 2007, accepted for publication 30 August 2007
Published 24 September 2007
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Poly(lactic acid) (PLA) based nanocomposites—a novel way of drug-releasing
Chen Chen et al 2007 Biomed. Mater. 2 L1
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