Zhidao Xia and James T Triffitt 2006 Biomed. Mater. 1 R1 doi:10.1088/1748-6041/1/1/R01
A review on macrophage responses to biomaterials
REVIEW ARTICLEZhidao Xia and James T Triffitt
Show affiliationsTOPICAL REVIEW
Macrophages are the dominant infiltrating cells that respond rapidly to biomaterial implantation in soft and hard tissues. These cells and their fused morphologic variants, multinucleated giant cells or foreign body giant cells, usually remain at biomaterial–tissue interfaces for the lifetime of the device in vivo. As a component of the immune system, macrophage activities are closely related to immune responses, inflammation and foreign body responses. However, macrophages also mediate biodegradation of bioresorbable materials via phagocytosis and extracellular degradation. In addition, macrophages are essential for effective tissue regeneration as they regulate the recruitment, proliferation and differentiation of target cells, such as fibroblasts, osteoblasts, endothelial cells and keratinocytes during healing processes.
- PACS
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87.15.K- Molecular interactions; membrane-protein interactions
- Subjects
- Dates
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Issue 1 (March 2006)
Received 13 January 2006, accepted for publication 8 February 2006
Published 1 March 2006
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A review on macrophage responses to biomaterials
Zhidao Xia and James T Triffitt 2006 Biomed. Mater. 1 R1
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