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Synchrotron X-ray microscopy and spectroscopy analysis of iron in hemochromatosis liver and intestines

J Y Peter Ko1,4, Tsun-Kong Sham1,4, Subrata Chakrabarti2 and Paul C Adams2,3

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Hemochromatosis is a genetic disorder that causes body to store excess iron in organs such as heart or liver. Distribution of iron, as well as copper, zinc and calcium, and chemical identity of iron in hemochromatosis liver and intestine were investigated by X-ray microprobe experiments, which consist of X-ray microscopy and micro-X-ray absorption fine structure. Our results show that iron concentration in hemochromatosis liver tissue is high, while much less Fe is found in intestinal tissue. Moreover, chemical identity of Fe in hemochromatosis liver can be identified. X-ray microprobe experiments allows for examining elemental distribution at an excellent spatial resolution. Moreover, chemical identity of element of interest can be obtained.


PACS

87.64.kd X-ray and EXAFS

87.15.N- Properties of solutions of macromolecules

87.59.-e X-ray imaging

Subjects

Medical physics

Biological physics

Dates

Issue 1 (2009)



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