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Degradation of platinum based anticancer drugs by methionine: An EXAFS study

K Provost1, D Bouvet-Muller1, S Crauste-Manciet2, L Olivi3, G Vlaic3 and A Michalowicz1

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We characterized the structures in solution of carboplatin and oxaliplatin degradation products in presence of a large excess of methionine (Met). The reaction of carboplatin leads to the formation of cis-Pt(Met)2 while, in the case of oxaliplatin, methionine displaces only the oxalate ligand to form Pt(diaminocyclohexane)(Met).


PACS

87.64.kd X-ray and EXAFS

87.15.B- Structure of biomolecules

87.19.X- Diseases

87.15.R- Reactions and kinetics

Subjects

Medical physics

Biological physics

Dates

Issue 1 (2009)



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