Initially invented to image surfaces down to atomic scale, the scanning tunneling microscope (STM) has been further developed in the last few years to an operative tool, with which atoms and molecules can be manipulated at low substrate temperatures at will with atomic precision in different manners by using solely the tip-adparticle forces. In this way various artificial structures on naoscale have been created and in situ characterized with the STM. Such structures as well as single molecules can be investigated by scanning tunnelling spectroscopy (STS) both with respect to their local electronic and even vibrational properties. Modifications of single molecules can be induced by using the tunnelling electron current: Rotations, diffusional jumps, vibrational excitations, desorption, dissociation and even association can be induced in individual molecules, often in a rather precise way by tuning the voltage into the energy levels of specific vibrations or electronic levels. These possibilities give rise to startling new opportunities for physical and chemical experiments on the single atom and single molecule level. Here a brief overview on results obtained with these new techniques is given.