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A minimal stochastic model for influenza evolution

F Tria1, M Lässig2, L Peliti3,4 and S Franz1

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We introduce and discuss a minimal individual based model for influenza dynamics. The model takes into account the effects of specific immunization against viral strains, but also infectivity randomness and the presence of a short lived strain-transcending immunity recently suggested in the literature. We show by simulations that the resulting model exhibits substitution of viral strains along the years, but that their divergence remains bounded. We also show that dropping any of these features results in a drastically different behaviour, leading either to the extinction of the disease, to the proliferation of the viral strains or to their divergence.


Keywords

mutational and evolutionary processes (theory)

new applications of statistical mechanics

PACS

87.23.Kg Dynamics of evolution

02.50.Fz Stochastic analysis

87.15.H- Dynamics of biomolecules

87.17.Ee Growth and division

MSC

92D30 Epidemiology

92D10 Genetics (For genetic algebras, see 17D92)

92C37 Cell biology

60H30 Applications of stochastic analysis (to PDE, etc.)

Subjects

Computational physics

Biological physics

Environmental and Earth science

Dates

Issue 07 (July 2005)

Received 18 May 2005, accepted for publication 18 July 2005

Published 27 July 2005



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