C Hauptmann et al 2009 J. Neural Eng. 6 066003 doi:10.1088/1741-2560/6/6/066003
C Hauptmann1, J-C Roulet2, J J Niederhauser2, W Döll2, M E Kirlangic1,3, B Lysyansky1, V Krachkovskyi1, M A Bhatti4, U B Barnikol1,3, L Sasse5, C P Bührle3, E-J Speckmann5, M Götz4, V Sturm3, H-J Freund1, U Schnell2 and P A Tass1,3,6
Show affiliationsIn the past decade deep brain stimulation (DBS)—the application of electrical stimulation to specific target structures via implanted depth electrodes—has become the standard treatment for medically refractory Parkinson's disease and essential tremor. These diseases are characterized by pathological synchronized neuronal activity in particular brain areas. We present an external trial DBS device capable of administering effectively desynchronizing stimulation techniques developed with methods from nonlinear dynamics and statistical physics according to a model-based approach. These techniques exploit either stochastic phase resetting principles or complex delayed-feedback mechanisms. We explain how these methods are implemented into a safe and user-friendly device.
87.80.-y Biophysical techniques (research methods)
87.19.R- Mechanical and electrical properties of tissues and organs
Issue 6 (December 2009)
Received 29 May 2009, accepted for publication 24 September 2009
Published 16 October 2009
C Hauptmann et al 2009 J. Neural Eng. 6 066003
R Neu et al 2007 Plasma Phys. Control. Fusion 49 B59