Xiao Liu et al 2009 J. Neural Eng. 6 065002 doi:10.1088/1741-2560/6/6/065002
Xiao Liu, Kerry J Gilmore, Simon E Moulton and Gordon G Wallace1
Show affiliationsThe purpose of this work was to investigate for the first time the potential biomedical applications of novel polypyrrole (PPy) composites incorporating a large polyelectrolyte dopant, poly (2-methoxy-5 aniline sulfonic acid) (PMAS). The physical and electrochemical properties were characterized. The PPy/PMAS composites were found to be smooth and hydrophilic and have low electrical impedance. We demonstrate that PPy/PMAS supports nerve cell (PC12) differentiation, and that clinically relevant 250 Hz biphasic current pulses delivered via PPy/PMAS films significantly promote nerve cell differentiation in the presence of nerve growth factor (NGF). The capacity of PPy/PMAS composites to support and enhance nerve cell differentiation via electrical stimulation renders them valuable for medical implants for neurological applications.
87.19.R- Mechanical and electrical properties of tissues and organs
Issue 6 (December 2009)
Received 9 April 2009, accepted for publication 7 July 2009
Published 23 October 2009
Xiao Liu et al 2009 J. Neural Eng. 6 065002
K M de Beurs et al 2009 Environ. Res. Lett. 4 045012
D Baumgardner et al 2008 Environ. Res. Lett. 3 025010
A Schneider et al 2009 Environ. Res. Lett. 4 044003
Scott F. Anderson et al. 2008 The Astronomical Journal 135 2108
Marco Fatuzzo and Fulvio Melia 2003 ApJ 596 1035
Kurtis A. Williams and Michael Bolte 2007 The Astronomical Journal 133 1490
Y. Damerdji et al. 2007 The Astronomical Journal 133 1470
Béla Szilágyi et al 2007 Class. Quantum Grav. 24 S275
Basmah Riaz et al. 2009 ApJ 705 1173