C Hauptmann and P A Tass 2009 J. Neural Eng. 6 016004 doi:10.1088/1741-2560/6/1/016004
C Hauptmann1 and P A Tass1,2,3
Show affiliationsWe show that the dynamical multistability of a network of bursting subthalamic neurons, caused by synaptic plasticity has a strong impact on the stimulus-response properties when exposed to weak and short desynchronizing stimuli. Intriguingly, such stimuli can reliably shift the network from a stable state with pathological synchrony and connectivity to a stable desynchronized state with down-regulated connectivity. However, unlike in the case of stronger coordinated reset stimulation, after termination of weaker stimulation the network may undergo a transient rebound of synchrony. When the coordinated reset stimulation is even weaker and/or shorter, so that a single stimulation epoch is not effective, the network dynamics and connectivity can still be reshaped in a cumulative manner by repetitive stimulation delivery.
Issue 1 (February 2009)
Received 19 September 2008, accepted for publication 17 November 2008
Published 12 January 2009
C Hauptmann and P A Tass 2009 J. Neural Eng. 6 016004
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