Stepan Y Kruglikov et al 2008 J. Neural Eng. 5 133 doi:10.1088/1741-2560/5/2/004
Fully optimized discrimination of physiological responses to auditory stimuli
Stepan Y Kruglikov1,2, Sharmila Chari1, Paul E Rapp3, Steven L Weinstein1,4, Barbara K Given1,5 and Steven J Schiff1,6,7
Show affiliationsThe use of multivariate measurements to characterize brain activity (electrical, magnetic, optical) is widespread. The most common approaches to reduce the complexity of such observations include principal and independent component analyses (PCA and ICA), which are not well suited for discrimination tasks. We addressed two questions: first, how do the neurophysiological responses to elongated phonemes relate to tone and phoneme responses in normal children, and, second, how discriminable are these responses. We employed fully optimized linear discrimination analysis to maximally separate the multi-electrode responses to tones and phonemes, and classified the response to elongated phonemes. We find that discrimination between tones and phonemes is dependent upon responses from associative regions of the brain apparently distinct from the primary sensory cortices typically emphasized by PCA or ICA, and that the neuronal correlates corresponding to elongated phonemes are highly variable in normal children (about half respond with neural correlates of tones and half as phonemes). Our approach is made feasible by the increase in computational power of ordinary personal computers and has significant advantages for a wide range of neuronal imaging modalities.
- PACS
-
43.64.Me Effects of electrical stimulation, cochlear implant
87.80.-y Biophysical techniques (research methods)
02.70.Rr General statistical methods
43.64.Pg Electrophysiology of the auditory nerve
87.19.R- Mechanical and electrical properties of tissues and organs
- Subjects
- Dates
-
Issue 2 (June 2008)
Received 19 November 2007, accepted for publication 19 March 2008
Published 22 April 2008
-
Fully optimized discrimination of physiological responses to auditory stimuli
Stepan Y Kruglikov et al 2008 J. Neural Eng. 5 133
-
Fabrication of submicrometre buried gold - palladium wires on
using electron beam lithography
V Rousset et al 1996 Nanotechnology 7 144
-
Clauser–Horne inequality for the full counting statistics
Fabio Taddei et al 2005 New J. Phys. 7 183
-
Noninvasive experimental control of beam profiles in nonlinear optics
E Benkler et al 2000 J. Opt. A: Pure Appl. Opt. 2 303
-
Measurement of mass transfer by an electrical conductivity method
E W Gaylord and W Forstall 1955 Br. J. Appl. Phys. 6 135
-
Nanometre diameter fibres of polymer, produced by electrospinning
Darrell H Reneker and Iksoo Chun 1996 Nanotechnology 7 216
-
Comments on the identification of high-order spectral lines of donors in semiconductors in intermediate magnetic fields
C J Armistead et al 1989 Semicond. Sci. Technol. 4 557
-
Spin dynamics in the organic spin - Peierls system MEM(TCNQ)
studied using muon-spin relaxation
S J Blundell et al 1997 J. Phys.: Condens. Matter 9 L119
-
Experimental control of free and forced structural vibration using a linear coupling strategy
F Fariborzi et al 1997 Smart Mater. Struct. 6 540
-
Magneto-optical investigations of superconductors
M R Koblischka and R J Wijngaarden 1995 Supercond. Sci. Technol. 8 199
Users also read
What's this?- Control of a humanoid robot by a noninvasive brain–computer interface in humans
- A high performance sensorimotor beta rhythm-based brain–computer interface associated with human natural motor behavior
- Kalman filter control of a model of spatiotemporal cortical dynamics