A Kabakçıoğlu et al 2010 Phys. Biol. 7 046005 doi:10.1088/1478-3975/7/4/046005
A Kabakçıoğlu1, D Yuret2, M Gür2 and B Erman2
Show affiliationsWe develop a general framework for the analysis of residue fluctuations that simultaneously incorporates anharmonicity and mode-coupling in a unified formalism. We show that both deviations from the Gaussian model are important for modeling the multidimensional energy landscape of the protein Crambin (1EJG) in the vicinity of its native state. The effect of anharmonicity and mode-coupling on the fluctuational entropy is in the order of a few percent.
87.15.H- Dynamics of biomolecules
02.50.-r Probability theory, stochastic processes, and statistics
Issue 4 (December 2010)
Received 1 June 2010, accepted for publication 28 September 2010
Published 26 October 2010
A Kabakçıoğlu et al 2010 Phys. Biol. 7 046005
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