Y Y Biton and S A Safran 2009 Phys. Biol. 6 046010 doi:10.1088/1478-3975/6/4/046010
The cellular response to curvature-induced stress
Y Y Biton and S A Safran
Show affiliationsWe present a theoretical model to explain recent observations of the orientational response of cells to unidirectional curvature. Experiments show that some cell types when plated on a rigid cylindrical surface tend to reorient their shape and stress fibers along the axis of the cylinder, while others align their stress fibers perpendicular to that axis. Our model focuses on the competition of the shear stress—that results from cell adhesion and active contractility—and the anisotropic bending stiffness of the stress fibers. We predict the cell orientation angle that results from the balance of these two forces in a mechanical equilibrium. The conditions under which the different experimental observations can be obtained are discussed in terms of the theory.
- PACS
-
87.17.Aa Modeling, computer simulation of cell processes
87.19.R- Mechanical and electrical properties of tissues and organs
- Subjects
- Dates
-
Issue 4 (December 2009)
Received 25 May 2009, accepted for publication 23 September 2009
Published 20 October 2009
-
-
The cellular response to curvature-induced stress
Y Y Biton and S A Safran 2009 Phys. Biol. 6 046010
-
Extended Anomalous Foreground Emission in the WMAP Three-Year Data
Gregory Dobler and Douglas P. Finkbeiner 2008 ApJ 680 1222
-
MOTESS: The Moving Object and Transient Event Search System
Roy A. Tucker 2007 The Astronomical Journal 134 1483
-
Persistence and survival in equilibrium step fluctuations
M Constantin et al J. Stat. Mech. (2007) P07011
-
Lithium Abundances of Extremely Metal-Poor Turnoff Stars
Wako Aoki et al. 2009 ApJ 698 1803
-
Control of a brain–computer interface without spike sorting
George W Fraser et al 2009 J. Neural Eng. 6 055004
-
Chandra Observations of the Northeastern Rim of the Cygnus Loop
Satoru Katsuda et al. 2008 ApJ 680 1198
-
Speckle Interferometry at the US Naval Observatory. VI.
Brian D. Mason et al. 2000 The Astronomical Journal 120 1120
-
LDA + Gutzwiller method for correlated electron systems
XiaoYu Deng et al 2008 EPL 83 37008
-
An initial analysis of options for a UK feed-in tariff for photovoltaic energy, from an array owner's viewpoint
Steve Plater 2009 Environ. Res. Lett. 4 044004
Users also read
What's this?- Membrane-mediated interactions drive the condensation and coalescence of FtsZ rings
- Desipramine induces disorder in cholesterol-rich membranes: implications for viral trafficking
- Comparative analysis of rigidity across protein families