Suman K Banik et al 2009 Phys. Biol. 6 046008 doi:10.1088/1478-3975/6/4/046008
Suman K Banik1, Andrew T Fenley and Rahul V Kulkarni2
Show affiliationsWe present a framework for analyzing luminescence regulation during quorum sensing in the bioluminescent bacterium Vibrio harveyi. Using a simplified model for signal transduction in the quorum sensing pathway, we identify key dimensionless parameters that control the system's response. These parameters are estimated using experimental data on luminescence phenotypes for different mutant strains. The corresponding model predictions are consistent with results from other experiments which did not serve as input for determining model parameters. Furthermore, the proposed framework leads to novel testable predictions for luminescence phenotypes and for responses of the network to different perturbations.
87.17.Jj Cell locomotion, chemotaxis
87.15.M- Spectra of biomolecules
87.10.-e General theory and mathematical aspects
Issue 4 (December 2009)
Received 10 February 2009, accepted for publication 23 September 2009
Published 20 October 2009
Suman K Banik et al 2009 Phys. Biol. 6 046008
J C Reichert et al 2009 Biomed. Mater. 4 065001