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A model for signal transduction during quorum sensing in Vibrio harveyi

Suman K Banik1, Andrew T Fenley and Rahul V Kulkarni2

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We present a framework for analyzing luminescence regulation during quorum sensing in the bioluminescent bacterium Vibrio harveyi. Using a simplified model for signal transduction in the quorum sensing pathway, we identify key dimensionless parameters that control the system's response. These parameters are estimated using experimental data on luminescence phenotypes for different mutant strains. The corresponding model predictions are consistent with results from other experiments which did not serve as input for determining model parameters. Furthermore, the proposed framework leads to novel testable predictions for luminescence phenotypes and for responses of the network to different perturbations.


PACS

87.17.Jj Cell locomotion, chemotaxis

87.15.M- Spectra of biomolecules

87.10.-e General theory and mathematical aspects

87.16.Yc Regulatory genetic and chemical networks

87.16.Xa Signal transduction and intracellular signaling

Subjects

Biological physics

Dates

Issue 4 (December 2009)

Received 10 February 2009, accepted for publication 23 September 2009

Published 20 October 2009

 
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