Antônio M Rodrigues et al 2009 Phys. Biol. 6 036010 doi:10.1088/1478-3975/6/3/036010
Palytoxin and the sodium/potassium pump—phosphorylation and potassium interaction
Antônio M Rodrigues1,2, Antonio F C Infantosi2 and Antônio-Carlos G de Almeida1,3
Show affiliationsWe proposed a reaction model for investigating interactions between K+ and the palytoxin–sodium–potassium (PTX–Na+/K+) pump complex under conditions where enzyme phosphorylation may occur. The model is composed of (i) the Albers–Post model for Na+/K+–ATPase, describing Na+ and K+ pumping; (ii) the reaction model proposed for Na+/K+–ATPase interactions with its ligands (Na+, K+, ATP, ADP and P) and with PTX. A mathematical model derived for representing the reactions was used to simulate experimental studies of the PTX-induced current, in different concentrations for the pump ligands. The simulations allow interpretation of the simultaneous action of Na+/K+–ATPase phosphorylation and K+ on the PTX-induced channels. The results suggest that (i) phosphorylation increases the PTX toxic effect, increasing its affinity and reducing the K+ occlusion rate, and (ii) K+ causes channel blockage, increases the toxin dissociation rate and impedes the induced channel phosphorylation, implying reduction of the PTX toxic effect.
- PACS
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87.16.Uv Active transport processes
87.16.D- Membranes, bilayers, and vesicles
87.19.R- Mechanical and electrical properties of tissues and organs
- Subjects
- Dates
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Issue 3 (September 2009)
Received 2 February 2009, accepted for publication 28 April 2009
Published 21 May 2009
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Palytoxin and the sodium/potassium pump—phosphorylation and potassium interaction
Antônio M Rodrigues et al 2009 Phys. Biol. 6 036010
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