Namiko Mitarai et al 2007 Phys. Biol. 4 164 doi:10.1088/1478-3975/4/3/003
Efficient degradation and expression prioritization with small RNAs
Namiko Mitarai1,2, Anna M C Andersson1, Sandeep Krishna1, Szabolcs Semsey1,3 and Kim Sneppen1
Show affiliationsWe build a simple model for feedback systems involving small RNA (sRNA) molecules based on the iron metabolism system in the bacterium E. coli, and compare it with the corresponding system in H. pylori which uses purely transcriptional regulation. This reveals several unique features of sRNA-based regulation that could be exploited by cells. Firstly, we show that sRNA regulation can maintain a smaller turnover of target mRNAs than transcriptional regulation, without sacrificing the speed of response to external shocks. Secondly, we propose that a single sRNA can prioritize the usage of different target mRNAs. This suggests that sRNA regulation would be more common in more complex systems which need to co-regulate many mRNAs efficiently.
- PACS
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87.15.R- Reactions and kinetics
87.15.A- Theory, modeling, and computer simulation
- Subjects
- Dates
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Issue 3 (September 2007)
Received 28 June 2007, accepted for publication 20 August 2007
Published 2 October 2007
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Efficient degradation and expression prioritization with small RNAs
Namiko Mitarai et al 2007 Phys. Biol. 4 164
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