G Tiana et al 2007 Phys. Biol. 4 R1 doi:10.1088/1478-3975/4/2/R01
Oscillations and temporal signalling in cells
REVIEW ARTICLEG Tiana1, S Krishna2, S Pigolotti3, M H Jensen2 and K Sneppen2
Show affiliationsREVIEW ARTICLE
The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show 'ultradian' oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-κB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.
- PACS
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87.85.Xd Dynamical, regulatory, and integrative biology
87.16.Yc Regulatory genetic and chemical networks
87.16.Xa Signal transduction and intracellular signaling
- Subjects
- Dates
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Issue 2 (June 2007)
Received 9 March 2007, accepted for publication 2 May 2007
Published 18 May 2007
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Oscillations and temporal signalling in cells
G Tiana et al 2007 Phys. Biol. 4 R1
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