Normand Mousseau et al 2005 Phys. Biol. 2 S101 doi:10.1088/1478-3975/2/4/S04
Navigation and analysis of the energy landscape of small proteins using the activation–relaxation technique
Normand Mousseau1, P Derreumaux2 and G Gilbert1
Show affiliationsThe resolution of the protein folding problem has been tied to the development of a detailed understanding of the configurational energy or of the free energy landscape associated with these molecules. Using the activation–relaxation technique and a simplified energy model, we present here a detailed analysis of the energy landscape of 16-residue peptide that folds into a β-hairpin. Our results support the concept of an energy landscape with an effective topology consistent with a scale-free network.
- PACS
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87.15.Cc Folding: thermodynamics, statistical mechanics, models, and pathways
87.15.H- Dynamics of biomolecules
- Subjects
- Dates
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Issue 4 (December 2005)
Received 15 May 2005, accepted for publication 28 July 2005
Published 9 November 2005
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Navigation and analysis of the energy landscape of small proteins using the activation–relaxation technique
Normand Mousseau et al 2005 Phys. Biol. 2 S101
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