Jaime E Santos et al 2005 Phys. Biol. 2 207 doi:10.1088/1478-3975/2/3/008
Renewal processes and fluctuation analysis of molecular motor stepping
Jaime E Santos1, Thomas Franosch1,2, Andrea Parmeggiani3 and Erwin Frey2
Show affiliationsWe present a systematic method of analysis of experiments performed with single motor proteins. The use of such a method should allow a more detailed description of the motor's chemical cycle through the precise fitting of the experimental data. We model the dynamics of a processive or rotary molecular motor using a renewal process, in line with the work initiated by Svoboda, Mitra and Block. We apply a functional technique to compute different types of multiple-time correlation function of the renewal process, which have applications to bead-assay experiments performed both with processive molecular motors, such as myosin V and kinesin, and rotary motors, such as F1-ATPase.
- PACS
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87.15.A- Theory, modeling, and computer simulation
87.16.Nn Motor proteins (myosin, kinesin dynein)
- Subjects
- Dates
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Issue 3 (September 2005)
Received 29 May 2005, accepted for publication 21 September 2005
Published 13 October 2005
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Renewal processes and fluctuation analysis of molecular motor stepping
Jaime E Santos et al 2005 Phys. Biol. 2 207
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