Toyoyuki Kitamura et al 2005 Phys. Biol. 2 200 doi:10.1088/1478-3975/2/3/007
A model on the origin of RNA
Toyoyuki Kitamura1,2, Michel Peyrard1 and Santiago Cuesta Lopez1,3
Show affiliationsThe theory of the liquid–glass transition is extended to describe the polymerization of RNA in a nucleotide-condensed state. In the glassy state the ribose subunits are joined by a 2'–5' or 3'–5' phosphodiester linkage to form the ribose–phosphate backbone similar to oligosaccharides and polysaccharides. The occurrence of the glass transition requires two conditions: (1) a supercooled state in a nucleotide-condensed state should exist below the temperature at which the whole RNA hydrolyzes; (2) the Gibbs free energy due to the Kauzmann entropy, which obeys a Curie law with a negative sign, must be larger than the height of the potential barrier for nucleotides to overcome to form the binding.
- PACS
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87.15.B- Structure of biomolecules
- Subjects
- Dates
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Issue 3 (September 2005)
Received 8 April 2005, accepted for publication 12 September 2005
Published 29 September 2005
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A model on the origin of RNA
Toyoyuki Kitamura et al 2005 Phys. Biol. 2 200
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