Ivica Reš and Olivier Lichtarge 2005 Phys. Biol. 2 S36 doi:10.1088/1478-3975/2/2/S04
Character and evolution of protein–protein interfaces
Ivica Reš and Olivier Lichtarge
Show affiliationsProtein–protein interactions create the macromolecular assemblies and sequential signaling pathways essential for cell function. Their number far exceeds the number of proteins themselves and their experimental characterization, while improving, remains relatively slow. For these reasons, novel computational methods have important roles to play in understanding the physical basis of protein interactions, and in constraining the molecular basis of their specificity. This paper discusses methods based on multiple sequence alignments of protein homologues and phylogenetic trees.
- PACS
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87.15.K- Molecular interactions; membrane-protein interactions
87.15.Cc Folding: thermodynamics, statistical mechanics, models, and pathways
87.16.Ka Filaments, microtubules, their networks, and supramolecular assemblies
- Subjects
- Dates
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Issue 2 (June 2005)
Received 7 March 2005, accepted for publication 9 May 2005
Published 27 May 2005
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Character and evolution of protein–protein interfaces
Ivica Reš and Olivier Lichtarge 2005 Phys. Biol. 2 S36
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