F Hayot and C Jayaprakash 2004 Phys. Biol. 1 205 doi:10.1088/1478-3967/1/4/002
The linear noise approximation for molecular fluctuations within cells
F Hayot1,2 and C Jayaprakash1
Show affiliationsWe study the applicability of Van Kampen's linear noise approximation to the calculation of fluctuations in cells due to small number of molecules for simple genetic systems not previously considered. These systems include dimer formation and feedback. We explain why the linear noise approximation can be surprisingly effective, but also illustrate how it fails in a simple example when a protein probability distribution is not purely Gaussian.
- PACS
- Subjects
- Dates
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Issue 4 (December 2004)
Received 5 August 2004, accepted for publication 13 October 2004
Published 16 November 2004
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The linear noise approximation for molecular fluctuations within cells
F Hayot and C Jayaprakash 2004 Phys. Biol. 1 205
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