Jonathan P K Doye et al 2004 Phys. Biol. 1 P9 doi:10.1088/1478-3967/1/1/P02
Inhibition of protein crystallization by evolutionary negative design
Jonathan P K Doye, Ard A Louis and Michele Vendruscolo
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Why are proteins so hard to crystallize? We propose an 'evolutionary negative design' principle to explain this difficulty. Proteins have evolved to avoid crystallization because crystallization compromises the viability of the cell. Evolutionary negative design is supported by much evidence in the literature, including the effect of mutations on the crystallizability of a protein, the correlations found in the properties of crystal contacts in bioinformatics databases, and the positive use of protein crystallization by bacteria and viruses.
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Issue 1 (March 2004)
Received 2 October 2003, accepted for publication 18 December 2003
Published 12 February 2004
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Inhibition of protein crystallization by evolutionary negative design
Jonathan P K Doye et al 2004 Phys. Biol. 1 P9
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