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Deutsche Physikalische Gessellschaft IOP Institute of Physics

Visualization of spiral and scroll waves in simulated and experimental cardiac tissue

Focus on Visualization in Physics

E M Cherry and F H Fenton

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Figure 1. (0.4 and 0.3 MB, GIF) (a)–(c) A canine ventricular myocyte during contraction in response to an electric field pulse. (d) 3D reconstructed canine ventricular myocyte.

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Figure 2. (Java applet) Human torso with heart in VF

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Figure 6(a) and (b). (Java applets) Examples of ionic models of cardiac electrophysiology.

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Figure 7. (Java applet) Interactive structure of the heart.

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Figure 8(a)–(d). (Java applets) Images of 3D cardiac structures.

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Figure 9. (Java applet) Reconstructed equine cardiac anatomy together with the MRI images from which it was developed.

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Figure 10. (Java applet) Blood vessels in the heart.

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Figure 11. (3.9 MB, GIF) Purkinje system in right ventricular canine tissue: simulated propagation along the network.

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Figure 12. (0.7 MB, GIF) Experimental (left) and simulated (right) anatomical reentrant arrhythmia.

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Figure 12(a). (4.5 MB, MOV) Experimental anatomical reentrant arrhythmia.

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Figure 13. (Java applet) Example of reentry in a 1D ring.

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Figure 14. (0.3, 0.2 and 0.7 MB, GIF) Initiation of reentry during the vulnerable window. Point stimulus applied too late (left), too early (middle) and during the vulnerable window (right).

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Figure 15. (0.1, 0.8, 0.5, 0.5, 0.9 and 0.7 MB, GIF) Six different types of spiral wave tip trajectories.

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Figure 17. (0.2 and 0.3 MB, GIF) Reentrant wave trajectories in experimental preparations. (Left) Circular trajectory in canine atrium with 3μM ACh. (Right) Linear trajectory in canine ventricle.

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Figure 18(b). (1.7 MB, MOV) Optical signal from canine left ventricular epicardium showing alternans during pacing at a CL of 185 ms.

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Figure 19. (Java applets) Maps of alternans in (a)–(b) voltage, and (c) calcium.

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Figure 20. (Java applet) Spatially discordant alternans in a simulated 1D cable.

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Figure 21. (2.8 MB, MOV) Spatially discordant alternans progressing to spiral wave breakup.

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Figure 22. (2.5 MB, GIF) 'Mother rotor' with fibrillatory conduction and breakup.

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Figure 23. (8.8 MB, GIF) Breakup of reentrant waves in canine left ventricle.

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Figure 24. (10.0 MB, MOV) Optical signal from canine left ventricular epicardium showing alternans during pacing at a CL of 185 ms.

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Figure 25. (4.1 and 2.0 MB, MOV) Canine atrial preparation with two different types of spiral wave dynamics.

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Figure 27. (1.2 and 2.0 MB, GIF) Spiral wave dynamics of the ten Tusscher et al model.

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Figure 28. (0.3 MB MOV and 0.6 MB GIF) Left: Top view and view of the vortex filament together with the voltage in different planes. Right: Views during rotation of a scroll ring.

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Figure 29. (Java applets) Breakup of scroll waves in a simulated 3D tissue slab.

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Figure 30. (1.3 MB MOV and Java applet) Reentrant spiral wave on the surfaces of a canine ventricular preparation and reconstructed 3D anatomy with overlaid optical mapping images during fibrillation.

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Figure 31. (5.7 and 2.5 MB, MOV) Single spiral wave in the rabbit ventricular geometry of [74] simulating VT. (b) Multiple spiral waves in the same geometry simulating VF.

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Figure 32. (1.4 and 1.1 MB, GIF) (a) Single spiral wave in the human atrial geometry of [76] simulating AFl. (b) Multiple spiral waves in the same geometry simulating AF.

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Figure 33. (Java applets) Arrhythmias in the context of the whole heart.

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Figure 34. (1.1 MB, MOV) Termination of equine AF by quinidine.

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Figure 35. (2.9 MB, MOV) Example of defibrillation following application of a high-energy shock in canine atrium.

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Figure 36. (Java applet and 0.3, 0.2 and 0.2 MB MOV) Formation of secondary sources in cardiac tissue.

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Figure 37. (2.7 and 1.6 MB, MOV) Simulated atrial fibrillation with inexcitable lesions simulating catheter ablation.

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Figure 38. (1.5 MB, GIF) Visualization of ventricular arrhythmias.



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