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'Plasma Healthcare' is an emerging interdisciplinary research
topic of rapidly growing importance, exploring considerable
opportunities at the interface of plasma physics, chemistry and
engineering with life sciences. Some of the scientific discoveries
reported so far have already demonstrated clear benefits for
healthcare in areas of medicine, food safety, environmental
hygiene, and cosmetics. Examples include ongoing studies of prion
inactivation, chronic wound treatment and plasma-mediated cancer
therapy. Current research ranges from basic physical processes,
plasma chemical design, to the interaction of plasmas with (i)
eukaryotic (mammalian) cells; (ii) prokaryotic (bacteria) cells,
viruses, spores and fungi; (iii) DNA, lipids, proteins and cell
membranes; and (iv) living human, animal and plant tissues in
the presence of biofluids. Of diverse interests in this new field
is the need for hospital disinfection, in particular with respect
to the alarming increase in bacterial resistance to antibiotics,
the concomitant needs in private practices, nursing homes etc, the
applications in personal hygiene—and the enticing possibility
to 'design' plasmas as possible pharmaceutical products, employing
ionic as well as molecular agents for medical treatment. The
'delivery' of the reactive plasma agents occurs at the gaseous
level, which means that there is no need for a carrier medium and
access to the treatment surface is optimal. This focus issue
provides a close look at the current state of the art in Plasma
Medicine with a number of forefront research articles as well as an
introductory review.
Focus on Plasma Medicine Contents
Application of epifluorescence
scanning for monitoring the efficacy of protein removal by RF
gas-plasma decontamination
Helen C Baxter, Patricia R Richardson, Gaynor A Campbell, Valeri
I Kovalev, Robert Maier, James S Barton, Anita C Jones, Greg
DeLarge, Mark Casey and Robert L Baxter
Inactivation factors of
spore-forming bacteria using low-pressure microwave plasmas in an N
2 and O
2 gas mixture
M K Singh, A Ogino and M Nagatsu
Degradation of adhesion molecules
of G361 melanoma cells by a non-thermal atmospheric pressure
microplasma
H J Lee, C H Shon, Y S Kim, S Kim, G C Kim and M G Kong
The acidification of lipid film
surfaces by non-thermal DBD at atmospheric pressure in air
A Helmke, D Hoffmeister, N Mertens, S Emmert, J Schuette and W
Vioel
Reduction and degradation of
amyloid aggregates by a pulsed radio-frequency cold atmospheric
plasma jet
D L Bayliss, J L Walsh, G Shama, F Iza and M G Kong
The effect of low-temperature
plasma on bacteria as observed by repeated AFM imaging
René Pompl, Ferdinand Jamitzky, Tetsuji Shimizu, Bernd
Steffes, Wolfram Bunk, Hans-Ulrich Schmidt, Matthias Georgi, Katrin
Ramrath, Wilhelm Stolz, Robert W Stark, Takuya Urayama, Shuitsu
Fujii and Gregor Eugen Morfill
Removal and sterilization of
biofilms and planktonic bacteria by microwave-induced argon plasma
at atmospheric pressure
Mi Hee Lee, Bong Joo Park, Soo Chang Jin, Dohyun Kim, Inho Han,
Jungsung Kim, Soon O Hyun, Kie-Hyung Chung and Jong-Chul
Park
Cell permeabilization using a
non-thermal plasma
M Leduc, D Guay, R L Leask and S Coulombe
Physical and biological
mechanisms of direct plasma interaction with living tissue
Danil Dobrynin, Gregory Fridman, Gary Friedman and Alexander
Fridman
Nosocomial infections-a new
approach towards preventive medicine using plasmas
G E Morfill, T Shimizu, B Steffes and H-U Schmidt
Generation and transport
mechanisms of chemical species by a post-discharge flow for
inactivation of bacteria
Takehiko Sato, Shiroh Ochiai and Takuya Urayama
Low pressure plasma discharges
for the sterilization and decontamination of surfaces
F Rossi, O Kylián, H Rauscher, M Hasiwa and D
Gilliland
Contribution of a portable air
plasma torch to rapid blood coagulation as a method of preventing
bleeding
S P Kuo, O Tarasenko, J Chang, S Popovic, C Y Chen, H W Fan, A
Scott, M Lahiani, P Alusta, J D Drake and M Nikolic
A two-dimensional cold
atmospheric plasma jet array for uniform treatment of large-area
surfaces for plasma medicine
QY Nie, Z Cao, C S Ren, D Z Wang and M G Kong
A novel plasma source for
sterilization of living tissues
E Martines, M Zuin, R Cavazzana, E Gazza, G Serianni, S
Spagnolo, M Spolaore, A Leonardi, V Deligianni, P Brun, M Aragona,
I Castagliuolo and P Brun
Designing plasmas for chronic
wound disinfection
T Nosenko, T Shimizu and G E Morfill
Plasma medicine: an introductory
review
M G Kong, G Kroesen, G Morfill, T Nosenko, T Shimizu, J van Dijk
and J L Zimmermann