David A Boas and Stephen J Payne 2009 Physiol. Meas. 30 L9 doi:10.1088/0967-3334/30/10/L01
David A Boas1 and Stephen J Payne2
Show affiliationsThe relationship between cerebral blood volume (CBV) and blood flow (CBF) has gained widespread interest because of its utility in using functional magnetic resonance imaging and optical imaging methods to estimate the cerebral metabolic rate of oxygen (CMRO2). A recent paper by Leung et al (2009 Physiol. Meas. 30 1–12) nicely presents measurements relating CBV to cerebral blood flow velocity (CBFV) as measured by near infrared spectroscopy and transcranial Doppler, respectively. They suggest that this relationship cannot be inverted to estimate CBF (or CBFV) from CBV, and that doing so to estimate CMRO2 is inappropriate. We argue that these data, and other related published data, do permit the estimation of CBF from CBV and thus enable CMRO2 to be estimated when only measures of CBV and deoxygenated hemoglobin are available.
87.61.Tg Clinical applications
Issue 10 (October 2009)
Received 1 April 2009, accepted for publication 18 August 2009
Published 18 September 2009
David A Boas and Stephen J Payne 2009 Physiol. Meas. 30 L9
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