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Method and device for bio-impedance measurement with hard-tissue applications

A Guimerà1, E Calderón2, P Los3 and A M Christie3

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Bio-impedance measurements can be used to detect and monitor several properties of living hard-tissues, some of which include bone mineral density, bone fracture healing or dental caries detection. In this paper a simple method and hardware architecture for hard tissue bio-impedance measurement is proposed. The key design aspects of such architecture are discussed and a commercial handheld ac impedance device is presented that is fully certified to international medical standards. It includes a 4-channel multiplexer and is capable of measuring impedances from 10 kΩ to 10 MΩ across a frequency range of 100 Hz to 100 kHz with a maximum error of 5%. The device incorporates several user interface methods and a Bluetooth link for bi-directional wireless data transfer. Low-power design techniques have been implemented, ensuring the device exceeds 8 h of continuous use. Finally, bench test results using dummy cells consisting of parallel connected resistors and capacitors, from 10 kΩ to 10 MΩ and from 20 pF to 100 pF, are discussed.


PACS

87.64.-t Spectroscopic and microscopic techniques in biophysics and medical physics

06.20.fb Standards and calibration

87.19.R- Mechanical and electrical properties of tissues and organs

Subjects

Instrumentation and measurement

Medical physics

Biological physics

Dates

Issue 6 (June 2008)

Received 30 November 2007, accepted for publication 23 April 2008

Published 11 June 2008



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