Ronald Aaron et al 2006 Physiol. Meas. 27 953 doi:10.1088/0967-3334/27/10/002
Ronald Aaron1, Gregory J Esper2, Carl A Shiffman1, Kaca Bradonjic1, Kyungmouk S Lee2 and Seward B Rutkove2
Show affiliationsElectrical impedance myography (EIM) is a painless and non-invasive technique for the assessment of muscle which we apply here to the effects of normal aging. The paper presents a cross-sectional analysis of EIM data from the quadriceps and tibialis anterior of 100 healthy subjects (44 men, 56 women, ages 18–90 years). The principal EIM parameter, the spatially averaged phase θavg, shows a roughly quadratic reduction with increasing age, declining more steeply beyond 60 years. The correlation was stronger in men (quadriceps: r2 = 0.68 for men, 0.52 for women; tibialis anterior: r2 = 0.74 for men, 0.38 for women; p < 0.001 throughout). Additionally, four subjects (age greater than 75 years) were asked to return for repeat testing several years after their initial assessment. These longitudinal results qualitatively confirm the cross-sectional data, though with greater reductions in θavg at high age. The findings of this study support the potential use of EIM as a simple and effort-independent test of muscle health in the elderly.
87.80.-y Biophysical techniques (research methods)
87.19.R- Mechanical and electrical properties of tissues and organs
Issue 10 (October 2006)
Received 22 May 2006, accepted for publication 30 June 2006
Published 25 July 2006
Ronald Aaron et al 2006 Physiol. Meas. 27 953
2002 Class. Quantum Grav. 19
S M Merkowitz et al 2005 Class. Quantum Grav. 22 S413
Vicent J. Martínez et al 2009 ApJ 696 L93
Theodore H Sweetser 2005 Class. Quantum Grav. 22 S429
R B Mann and M B Young 2007 Class. Quantum Grav. 24 951
C P Pang et al 2003 J. Phys. D: Appl. Phys. 36 1764
O Lavrova et al 2006 J. Phys.: Condens. Matter 18 S2657
Ian M Mills et al 2006 Metrologia 43 227
J Baudon et al 1999 J. Phys. B: At. Mol. Opt. Phys. 32 R173