Benoît Leboulanger et al 2004 Physiol. Meas. 25 R35 doi:10.1088/0967-3334/25/3/R01
Benoît Leboulanger1,2, Richard H Guy1,2 and M Begoña Delgado-Charro1,2
Show affiliationsIontophoresis is the application of a small electric current to enhance the transport of both charged and polar, neutral compounds across the skin. Manipulation of either the total charge delivered and/or certain electrode formulation parameters allows control of electromigration and electroosmosis, the two principal mechanisms of transdermal iontophoresis. While the approach has been mainly used for transdermal drug delivery, 'reverse iontophoresis', by which substances are extracted to the skin surface, has recently been the subject of considerable effort. Glucose monitoring has been extensively studied and other applications, including therapeutic drug monitoring, are contributing to the development of the technique. An internal standard calibration procedure may ultimately render this novel monitoring technique completely non-invasive.
87.16.Uv Active transport processes
87.19.R- Mechanical and electrical properties of tissues and organs
Issue 3 (June 2004)
Received 3 October 2003, accepted for publication 6 January 2004
Published 20 April 2004
Benoît Leboulanger et al 2004 Physiol. Meas. 25 R35
G N Peel 1937 J. Sci. Instrum. 14 103
M D Rogers 1962 J. Sci. Instrum. 39 317
Filipe Tostevin and Martin Howard 2006 Phys. Biol. 3 1
C C Paterson 1932 J. Sci. Instrum. 9 33
A El Badia et al 2005 Inverse Problems 21 1121
T M Rice and M Sigrist 1995 J. Phys.: Condens. Matter 7 L643
F Etayo Gordejuela and R Santamaría 2001 J. Phys. A: Math. Gen. 34 981
E A Garcia et al 1993 J. Phys.: Condens. Matter 5 A279
F Tria et al J. Stat. Mech. (2005) P07008