Oleg Y Grinberg et al 2004 Physiol. Meas. 25 659 doi:10.1088/0967-3334/25/3/006
Oleg Y Grinberg1, Huagang Hou1, Stalina A Grinberg1, Karen L Moodie2, Eugene Demidenko2, Bruce J Friedman2, Mark J Post3 and Harold M Swartz1
Show affiliationsOxygen tension (pO2) in muscles and regional blood flow were measured in a rabbit model of limb ischemia. pO2 was measured repetitively by EPR oximetry with EMS char in four different muscle groups in the same animals. Blood flow in the same muscles at several time points was measured using microspheres. A linear mixed effects model was developed to analyze the data on pO2 and blood flow. The results suggest that while under normal conditions pO2 in muscles does not depend significantly on blood flow, immediately after arterial occlusion pO2 correlates linearly with blood flow. Within two weeks of occlusion the pO2 is recovered to 45% of baseline. This study demonstrates, for the first time, the applicability of EPR oximetry in animals larger than rodents.
Issue 3 (June 2004)
Received 26 November 2003, accepted for publication 13 April 2004
Published 5 May 2004
Oleg Y Grinberg et al 2004 Physiol. Meas. 25 659
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