Jinlong Zhang et al 2008 J. Micromech. Microeng. 18 125025 doi:10.1088/0960-1317/18/12/125025
Jinlong Zhang1, Qiuquan Guo2, Mei Liu1 and Jun Yang1,2,3
Show affiliationsBlood separation is the first step for subsequent blood tests in clinical diagnosis. Lab-on-a-chip technology provides an automatic, cost-effective and fast solution for a wide variety of blood analyses. The objective of this work is to design a new lab-on-CD microstructure capable of separating blood cells from the whole blood into different reservoirs directly. A CD platform including a microchannel network consisting of a straight main microchannel, a curved microchannel and a branching microchannel has been proposed. The merits of this design are its simple structure, less operating time and high separation efficiency because it utilizes multiple separation mechanisms, for instance, two centrifugal forces and Coriolis force. One centrifugal force is due to the system rotation; the other centrifugal force is due to the curvature of the specifically designed curved channel. In this work, systematical evaluation on the functionality and performance of such a design has been done. Ninety-nine per cent separation efficiency is achieved for diluted blood of 6% hematocrit.
87.85.Ng Biological signal processing
Issue 12 (December 2008)
Received 29 July 2008, in final form 22 October 2008
Published 19 November 2008
Jinlong Zhang et al 2008 J. Micromech. Microeng. 18 125025
Sonia L'Innocente et al 2009 J. Phys. A: Math. Theor. 42 475305
Xue-Chai Chen et al 2008 Nanotechnology 19 235105
Magnus Rattray et al 2009 J. Phys.: Conf. Ser. 197 012002
E G Thorsteinsson and J T Gudmundsson 2010 Plasma Sources Sci. Technol. 19 015001
T Abe et al 2009 J. Phys.: Conf. Ser. 191 012023
E A Brener et al 2009 J. Phys.: Condens. Matter 21 464106
S Desai et al 2008 Class. Quantum Grav. 25 184024
A Ruiz et al 2007 Nanotechnology 18 505306
Dongmin Gang et al JHEP11(2009)024