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A combinatorial approach to microfluidic mixing

Peter B Howell Jr1, David R Mott2, Frances S Ligler1, Joel P Golden1, Carolyn R Kaplan2 and Elaine S Oran2

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A new computational approach to the modeling and design of efficient microfluidic mixers is demonstrated. The mixers created provide far more rapid mixing than previous designs. A set of mixer components is created and mapped using a traditional Navier–Stokes fluid solver. The maps are used to quickly model the effect each component has on the lateral distribution of species in the channel. For a mixer of a given length, all the possible combinations of components can be evaluated, and the best mixer for a given metric can be found. Although the mixers presented in this study are short (length-to-width ratios below 8), they show degrees of mixing comparable to much longer mixers found in the literature.


PACS

47.85.Np Fluidics

85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

47.51.+a Mixing

47.10.ad Navier-Stokes equations

47.61.Ne Micromixing

Subjects

Fluid dynamics

Mathematical physics

Electronics and devices

Nanoscale science and low-D systems

Dates

Issue 11 (November 2008)

Received 5 December 2007, in final form 8 February 2008

Published 7 October 2008



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